Press Left CTRL + ~ to bring up the cheat menu. These will disable achievements.

Effect	Code
Change weather	makeitrain
Director mode	jrtalent
Drunk mode	liquor
Explosive bullets	highex
Explosive melee attacks	hothands
Faster running	catchme
Faster swim	gotgills
Flaming bullets	incendiary
Give weapons and extra ammo	toolup
Invincibility (5 minutes)	painkiller
Low gravity	floater
Lower wanted level	lawyerup
Maximum health and armor	turtle
Raise wanted level	fugitive
Recharge ability instantly	powerup
Skyfall	skyfall
Slippery cars	snowday
Slow-motion aiming	deadeye
Slow-motion mode	slowmo
Spawn BMX bike	bandit
Spawn Buzzard attack helicopter	buzzoff
Spawn Caddy (golf cart)	holein1
Spawn Comet	comet
Spawn Duster (crop duster plane)	flyspray
Spawn Limo	vinewood
Spawn PCJ-600	rocket
Spawn Parachute	skydive
Spawn Rapid GT	rapidgt
Spawn Sanchez	offroad
Spawn Stunt Plane	barnstorm
Spawn Trashmaster	trashed
Super jump	hoptoit