Full Playthrough Guide...

Complete the indicated task to unlock the achievement.

Achievement	How to unlock
Anger is Fuel	Unlock the Seal of Ire.
Back to Work	Complete The Craftsman's questline by getting him all the tools he needs.
Bowed and Broken	Complete The Coward's questline by providing him his mead.
Burn the Witch	Kill the Witch of the Necrovale.
Close to the Gods	Upgrade an item to Tier 10.
Dat Drip	Have eighteen Legendary or Heroic items equipped.
Deep Night	Reach level 1,000 in the Path of Wotana.
Ember Mania	Get five or more Embers from one trip to the Ember Mine.
Endless Terror	Unlock the Seal of Fear.
Fate Means Nothing	Kill all the Guards in the Necrovale Entryway.
Fate be Damned	Escape from the Guards in the Necrovale Entryway.
Flikeryng Flamme	Complete The Seraph's questline, by sparking the flame of her memories.
For the Taking	Unlock the Seal of Greed.
Heroism	Find a Heroic-tier item.
I Like it When You Call Me	Get the Big Flopper weapon.
Into That Good Night	Die twenty times.
Kick Him While He's Down	Achieve the max reward tier in the Trial of Might.
Lost and Found	Complete The Wretch's questline by freeing him.
New Growth	Complete The Gardener's questline by helping him restore his Garden.
Pack Rat	Fill every space of your maxed out Stash.
Please Calm Down	Kill the Witch of the Necrovale in under five seconds.
Restocked	Complete The Merchant's questline by helping him fully restock.
Slipped Away	Avoid having to sacrifice anything when you succumb.
Some Price too High	Die to a Blood Sacrifice.
The Highest Station	Unlock the Seal of Arrogance.
The Weight of It All	Unlock the Seal of Shame.
Titrated	Complete The Alchemists' questline by getting him enough materials to complete his experiments.
Unashamed	Complete The Harlot's questline by helping her process her shame.
Where We Are All Bound	Succumb to despair.
Word to the Wise	Complete The Mystic's questline by drawing out his vision of the future.