For any Boss, a good strategy is to equip a special weapon that you can run with while shooting, such as the Machine Buster. If possible, take a Hyper Cartridge. Run around them using the sideways run, turning to adjust your path every once in a while. Along with jumping, you should be able to avoid most of the attacks. Shoot the special weapon to wear them down, and use your Buster to finish them off. Note: If you have the Laser, it is much more useful than any other weapon. Note: If you are fighting Juno, wait until it is in the second form to use the special weapon.