Full Gameplay Guide...

Complete the indicated task to unlock the achievement.

Achievement	How to unlock
Ani the Animator	Defeat The Harvester of Souls.
Bishop's Staff	Heal 10,000 health from Life Regen.
Branch of the Bog	Deal 1,000,000 Shadow Damage.
Champion's Blade	Defeat the Emperor.
Conduit Staff	Deal 1,000,000 Elemental Damage.
Crusader Shield	Get 75 Block Chance in a single run.
Edwin	Take 1000 damage in a single run.
Flintlock Pistols	Defeat the Countess.
Golden Spear	Deal 1,000,000 Holy Damage.
Holy Sceptre	Get Consecrate to level 20.
Krothug the Ogre	Upgrade the Blast Radius Bonus from any ability by 100%.
Mithril Daggers	Gain 200% additional Critical Hit Damage in a single run.
Necronomicon	Defeat the Harvester of Souls.
Soul of Frost	Defeat Chillgrave.
The Mad Mage	Cast 1000 abilities from triggers.
The Paladin	Heal for 1000 in a single run.
Tim	Pick up 50 consumables in a single run.
Vampire Spine	Heal 10,000 health from Life Steal.