Players may unlock gameplay modifiers through the completion of campaigns. Enabling Hyper Combat mode or Running Zombies will disable Steam Achievements and leaderboard functionality.

Unlockable	How to unlock
Big Head Mode	Beat the original Dead Pixels campaign on hard.
Black and White Mode	Beat at least 10 waves in Last Stand Survival mode.
Colorful Blood Mode	Beat the original Dead Pixels campaign on normal.
Hyper Combat Mode	Beat at least 10 waves in Last Stand Survival mode.
Running Zombies	Beat The Solution campaign.