Stay wet
Use your boost cards wisely and you're far more likely to succeed. Nerfing your opponent with the water gun early on will make them focus on taking out the card, leaving your other units free to attack. Remember though that cards remain changed even after the card has been destroyed. Get a card wet once and it'll stay wet throughout the rest of the game. If there's a water gun in play, get rid of it before throwing your best cards into the mix.