When selecting team abilities, consider Jammer. The CPU does not focus its fire on one target in most cases, however human opponents will often target your best character immediately. Jammer will randomize incoming attacks to spread them out over multiple characters. The Targeting ability is also important, especially with a team built around First Strike. If you roll First Strike to get the initiative and your opponent does not use Jammer, you can almost always take out an enemy character during the first turn.