Buying players
If you want to buy a player, bid for them about 1 or 2 million above the asking price. This ensures you of signing that player. Players that are worth buying include:
Thierry Henry
Ronaldinho
David Beckham
Ronaldo (either)
Tim Howard
Roberto Carlos
Alexandre Del Piero
David Bellion
Ruud Van Nistelrooy
Hernan Crespo
In the first year, it is almost impossible (unless you bid over 5 million above the asking price) to buy Thiery Henry, David Becham, Ronaldo, and Del Piero.
Easy win
Choose a side to play on. Then, during gameplay, press Start and choose "Select Sides". Move your controller under the opponent's side and resume gameplay. Then, score as many goals as desired (while under the opponent's side), then just switch back to your side again. This way you will have a big point lead, depending on how many goals you scored. This trick also works better when you switch back to your side near the end of the second half.
Getting good players
Go to the options menu then to "Player Swaps". Swap all the good players desired onto the team you want to play as, then save that as a squad. Call it whatever desired. Then go to "New Season" and select "Current Squads" and play your team. This is useful for a third division team. This team now has all the good players.
Good Players
Create a team with the following players. Note: The players are expensive so you might have to sell some of your best players first. The subs are up to you.
Defenders
RB: Michel Salgado (Real Madrid)
LCB: Fabio Cannavaro (Inter Milan)
RCB: Alessandro Nesta (AC Milan)
LB: Roberto Carlos (Real Madrid)
Midfielders
LM: Zinedine Zidane (Real Madrid)
RM: David Beckham (Real Madrid)
CAM: Ronaldiniho (Barcelona)
Strikers
LF: Ronaldo (Real Madrid)
RF: Theirry Henry (Arsenal)