Certain bosses are dealt extra damage when certain Jutsus are used on them.

Using Naruto's Harem no Jutsu on Ebisu will cause Ebisu to have a bloody nose and die instantly.

Using Kakashi's Dog Summoning no Jutsu on Zabuza will make all the dogs latch on to Zabuza, and Kakashi will preform Chidori on him, just like in the anime and manga.

Using Naruto's Harem no Jutsu on the 3th Hokage at the end of the final level will make give him a bloody nose also.