The St. Anger basic attack immediately damages enemies. Its effectiveness depends only on how fast you can tap. If other abilities are available, use them first. Keep all your abilities on cooldown but do not hesitate to use special abilities. Keep one big damage ability on backup just in case (for example, God Hammer). At about level 4, armored vehicles such as tanks and helicopters will begin to appear. Target them first. If they survive, they will do heavy damage. They are immune to elemental damage such as fire and lightning. Use physical damage from regular attacks to take them out.