Look out for the BFG bonus. This sends out a massive wave of attacks upon activation.
Elements
As the levels pass, other elements come into play. For example, from the second level onwards, mini-bombs pop up that head towards you like a magnet and break up into even smaller bombs upon impact.
Positioning
Taking down that robo-snake is all about positioning. It is possible to pull of two quick hits in a row if you manage to get close enough when the snake is changing direction in one of the corners.
Yellow shards
Pick up any yellow shards that fall to the floor when you take out an adversary. These add points to your total.