Hot sauce invincibility protects you from damage, such as colliding into enemies and spikes. However, dropping into water or falling off cliffs can still kill you. Enemies will run away while you are invincible. With the exception of turtles, they will run the opposite direction when you approach them with hot sauce. Make sure you are ready to chase them as soon as you collect the hot sauce bottle. To clear them out quickly, chase them off cliffs or into water.