She can be a bit difficult, but if you see the pattern, it will be easy. She will usually jump up on the top of the screen and spin. If she lands on the Mario's side, make Mario jump first, then Luigi, and vice versa. If she manages to jump in the middle, make them both jump at the same time to avoid damage. She will also spit out rocks at you. Try to break them, because you will be given items such as Ice Flowers, Fire Flowers, Coins and Mushrooms. Once you damage her enough times, she will break apart and have four mini versions of her. Pay attention to which eyebrow raises. That is the direction they will be going to. When they jump toward you, just hit them with the hammer. If they hit you enough times, you will get dizzy and may miss a couple turns. When it is your turn, get a Red Pepper and use Ice Flowers to hit them all. It might lower some defenses. Continue using Ice Flowers. It will then transform back to its bigger self and continue the same process. It may seem like the battle is endless, but continue the process and she will eventually be defeated.

When Ms.Thwomp is divided into four mini-Thwomps, take note of their teeth. You can see that all four are different. Attack the one that has the same teeth as the bigger one and the battle should end faster.