Character specific gear is very valuable. When picking up character specific items, such as "Iron Man's Coil", it is described as doing +3 Damage and +3 Rocket Uppercut. This is not +3 to damage for the hit; it means that it adds three dots in the Powers area. With this single item you can go from 129 Damage to 289 Damage.
Cheat Mode
Enter one of he following codes at the indicated screen to activate the corresponding cheat function:
All characters
At the main menu or a S.H.I.E.L.D. save zone menu, quickly press Up(2), Down(2), Left(3), Start to unlock all characters. If you entered the code correctly, you will hear a sound.
All powers
At the main menu or a S.H.I.E.L.D. save zone menu, quickly press Left, Right, Left, Right, Up, Down, Up, Down, Left, Right, Start to unlock all powers. If you entered the code correctly, you will hear a sound.
All costumes
At the main menu or a S.H.I.E.L.D. save zone menu, quickly press Up, Down, Up, Down, Left, Right, Left, Right, Up, Down, Start to unlock all costumes. If you entered the code correctly, you will hear a sound.
All cinematics
At the Review menu, quickly press Up, Left(2), Up, Right(2), Up, Start to unlock all cinematics.
All comic book covers
At the Review menu, quickly press Left, Right(2), Left, Up(2), Right, Start to unlock all comics.
All concept art
At the Review menu, quickly press Down(3), Right(2), Left, Down, Start to unlock all concept art.
All wallpapers
At the Review menu, quickly press Up, Down, Right, Left, Up(2), Down, Start to unlock all wallpapers.
The Courses
At the simulator terminal screen where you choose a Comic Book mission, quickly press Up, Right, Left, Down, Up, Right, Left, Down, Start to unlock The Courses.
Play as Daredevil
Go to a S.H.I.E.L.D. save zone and select "Change Team". Delete all selected characters. Once all of your team slots are empty, quickly press Left(2), Right(2), Up, Down, Up, Down, Start to unlock Daredevil. If you entered the code correctly, you will hear a sound. Note: This code may also be enabled at the main menu. Alternately, collect the five Daredevil action figures (one is found in each Act).
Play as Silver Surfer
Go to a S.H.I.E.L.D. save zone and select "Change Team". Delete all selected characters. Once all of your team slots are empty, quickly press Down, Left(2), Up, Right, Up, Down, Left, Start to unlock Silver Surfer. If you entered the code correctly, you will hear a sound. Note: This code may also be enabled at the main menu. Alternately, complete all Comic missions.
Invincibility
While playing the game, quickly press Up, Down, Up, Down, Up, Left, Down, Right, Start.
Level 30 team
At the team menu, quickly press Up, Left, Up, Left, Down, Right, Down, Right, Start.
Level 99 team
At the team menu, quickly press Up, Left, Up, Left, Down, Right, Down, Right, Plus.
100,000 Gold Coins
At the team menu, quickly press Up(3), Left, Right, Left, Start.
Touch of Death
While playing the game, quickly press Left, Right, Down(2), Right, Left, Start.
Super Speed
While playing the game, quickly press Up, Left, Up, Right, Down, Right, Start.
Filler
While playing the game, quickly press Left, Right(2), Left, Up, Down(2), Up, Start. Your extreme attack will always be available with no energy cost.
Easy Comic missions
To complete all the Comic missions easily and unlock Silver Surfer and get gold at the same time, wait and play all the missions at the end of the game when your characters have leveled up and have decent powers. If some are still to difficult to complete, play some Versus mode missions with those characters to level them up and/or pick up some Shield Tokens to add to their costume.
Easy Iron Man Comic mission
When you get to the end of the mission to battle Ultimo, run back to the door you came in. Ultimo is so big he cannot pass the edge of the room he is in. You can just keep hitting him with your ranged attacks, then when needed, fly in and collect the health and energy vials he drops.
Fourth alternate costume
Successfully complete the Combat Training challenge for a character to unlock his or her fourth costume. Alternately, get a "Bronze" rank in a character's Comic mission.
Hard mode
Successfully complete the game on the Normal difficulty setting to unlock the Hard difficulty setting.
Hard-to-beat team
Okay, the way I have a very hard to beat team is:
First use the 'All Characters' cheat.Then pick Ghost Rider. Level up his Penant Stare, Flechette Chain, and Damnation as much as possible. Next, you pick Doctor Strange. Level Up whatever you want on him. Next is Silver Surfer. Make sure you level up his 'Molecular Mix-up' and basic energy beam. Lastly, pick Spider-Man. Level up any long-range attacks from him. Those are good. I beat the game seven times in one day with this team.
How to beat mandrin
When mandrin has gone up in is teleport pad and released the spder bombs get a flying character. Hover over the correct teleport pad. The spiders will go under you and teleport into the room and blow up the ultimos so you can go on the teleport pad and attack mandrin.
Infinite Experience
In Mephisto's Realm in the beginning area with the alter that reads, "Thy way shall be lit by the flames of impure souls." you can garner huge amounts of XP (infinite, if you wish) in a very short amount of time. Where the demons spawn, they will instantly respawn after every death. This is the fastest respawn rate that I've run across in the game (much faster than the Omega Base simulation missions' infinite spawn room or the Asgard simulation area). The demons respawn so quickly, that throwing attacks that return (Thor's hammer throw, DD's Extensive Strike for example) can actually kill one on the way out and one on the way back.
If your heroes are capable of quickly killing (one or two attacks) these low HP mobs , you will rapidly level all of your heroes or get costumes of heroes you don't already have. Thor's Mjolnir's Might or Dare Devil's ES seem perfect for this and only get better as you quickly level. Alternatively, you could throw the demons over the edge (*not* into the lava in the center, or the portal will open and the mission is over) but it isn't very quick. There is no need to worry about mana expensive, the blue orbs start popping so quickly that soon all of the orbs are just adding to the XP.
After a very short period of time, you will start seeing full-momentum orbs start to pop out too, which means that you can start using your Extreme attacks on a regular basis. Rising 16 levels in less than a 30 minutes is probably very doable.
Play as Black Panther
Collect the five Black Panther action figures (one is found in each Act) to unlock him.
Play as Blade
Win the toy grab mini-game at the Carnival in Murderworld to unlock Blade.
Play as Dr. Strange
Save Dr. Strange in Mandarin's Palace to unlock him.
Play as Ghost Rider
Trade places with Ghost Rider in Hell in order to save his soul to unlock him.
Play as Nick Fury
Successfully complete the game to unlock Nick Fury.
Recommended team
Use the following trick to make a hard to kill team. Create a team consisting of Wolverine, Blade, Luke Cage, and Ghost Rider (Bad To The Bone team). The team bonus will be that 5% of all damage will be regained as health. Also, all these characters have a way to regenerate health. Equip the following outfits. For Wolverine, Astonishing, max out Health Regen and Defense. For Blade, Ultimate, max out Health Regen and Defense. For Luke Cage, New Avengers, max out Health Regen and Defense. For Ghost Rider, Original, max out Resurrect Ally and Defense. It is also recommended that Ghost Rider be equipped with The Heart Of Mephisto (10% of attack damage turned into health) or a similar item because he is the only character without a Health Regen. Equip other characters with gear that increases defense or dodging capabilities. Not only will your team be difficult to hurt, but they will be absorbing and regenerating most of the damage they take. If a teammate dies, Ghost Rider will have about a 50% chance of resurrecting them. Note: Ghost Rider is the weak character. He does not regenerate, and if he dies resurrection is lost. Also, Wolverine will regenerate the fastest because he has an inherit ability to regenerate in addition to the suit's bonus.
For easy health, experience, energy, money, and Extreme Momentum Orbs for leveling, create a team consisting of Luke Cage, Elektra, and Dr.Strange. When they each have a full Momentum bar, get a group of enemies around you. Then, use the power. Elektra will stun all enemies with her Curse of the Hand. Then, Dr. Strange will use his Mystic Maelstrom to kill all stunned enemies, causing them to drop Extreme Momentum Orbs for each enemy killed. Luke Cage will use his Sweet Christmas to kill any of the remaining enemies, giving you +472% more money for each enemy killed in the attack sequence. This trick is especially useful for leveling characters, unlocking costumes, and maxing out stats. The best place to do this is in the Shield training simulator on the Thunderball mission. Even if you run out of time you will still get the levels and money; do not worry about killing the Boss. Just get your momentum on Luke Cage, Dr. Strange, and Elektra.
Second and third alternate costumes
Gain between two and four levels with a character. Alternately, defeat 30 enemies with a character to unlock his or her second costume. Defeat 175 enemies with a character to unlock his or her third costume.
Team bonuses
Create a team with the indicated characters to receive the corresponding bonus:
Agents Of Shield (+5% to all resistances): Captain America, Nick Fury, Spider-Woman, Wolverine
Agile Warriors (+10% reduced energy cost): Spider-Man, Spider-Woman, Elektra, Deadpool
Air Force (+15% maximum health): Human Torch, Ms. Marvel, Storm, Thor
Alternate Identities (+5% criticals): Ironman - War Machine, Ghost Rider - Western, Spider-Woman - Secret Wars, Ms. Marvel - Ventura, Thor - Beta Ray Bill
Assassins (+60% for S.H.I.E.L.D.. credit drops): Blade, Deadpool, Elektra, Wolverine
Flashback (+15% max health): Iceman in Snowy Form, Captain America in WW2, Daredevil in Original, Ghost Rider in Original, Iron Man in Classic, Ms. Marvel in Original, Wolverine in Classic
Martial Artists (+15% striking): Black Panther, Captain America, Daredevil, Moon Knight, Nick Fury
Marvel Knights (+6% to all stats): Black Panther, Daredevil, Dr. Strange, Luke Cage, Spider-Man, Moon Knight
Marvel Royalty (+60% credit drop): Black Panther, Dr. Strange, Thor, Storm
Natural Forces (+5% damage inflicted as health gain): Thor, Storm, Human Torch, Ice Man
Natural Leaders (+5% XP): Captain America, Dr. Strange, Mr. Fantastic, Nick Fury, Storm
New Avengers (+5% to all resistances): Captain America, Luke Cage, Wolverine, Spider-Man, Spider-Woman
New Fantastic Four (+15% maximum energy): Ghost Rider, Luke Cage, Spider-Man, Wolverine
Power Platoon (+20% energy per KO): Silver Surfer, Iron Man, Ms. Marvel, Thor
Raven Ultimates (+6% to all stats): Deadpool, Colossus, Moon Knight, Thing
Scorchers (+10% reduced power cost): Ghost Rider, Human Torch, Storm, Thor
Supernaturals (+5% health regeneration): Blade, Dr. Strange, Ghost Rider, Thor
Think Tanks (+15% max health): Dr. Strange, Mr. Fantastic, Spider-Man, Iron Man
Weapons Specialists: Blade, Captain America, Deadpool, Elektra, Nick Fury
X-Men (+15% maximum energy): Colossus, Iceman, Storm, Wolverine