First, you must destroy the three antennas on top of the drone's head while dodging its attacks. This is somewhat difficult because they can be regenerated. The drone is now stunned and you are able to grapple it and open up the front of its head. Do this quickly because it is not stunned for long. Now, with its head open, it will fly to the ledges around you and shoot bombs at you. Shoot them before they get to you, because they home in on you and they also drop health and ammuntion. Go into hyper mode and shoot its open head. Use a charged shot for maximum damage. After you have done some damage to it, its head will close and you will have to repeat the process. Once you have done this several times, smoke fills the room and makes it difficult to see, and the drone regenerates its antenna very quickly so you must destroy them fast. After that, just go into hyper mode and blast the front off its head.