After you have completed the Final Showdown mission, swing somewhere far then go on the map and look for the Financial District. Go there. Go to the left until you see a glass building. That is the construction site after it was broken You will see the little square that you was fighting in with Venom and Sandman.
Defeating Lizard
You must first defeat Kraven The Hunter. Use the Black suit and it will be easy. You will then catch up with the new and improved Lizard. Stand by a generator and wait until he is about to strike, then dodge. He will hit the generator and shock himself. This will also shock you. Repeat this until you must counter-attack him and ride his back. Try to balance and he will run into one. When the last one shuts off, you must turn it back on. Go over to the switch and turn it back on. Ride his back one more time to defeat him.
Defeating Michael Morbius and Shriek
Wait until Michael is about to rush you, then open the window. He will be temporarily weakened. Beat him up. Shriek will heal him, losing some of her health. Repeat this until he dies, and she flees the scene.
Defeating Shriek
Shriek has a shield, so do not worry about her. Stand next to a satellite and wait for your Spidey senses to activate. Use them and dodge to cause her to damage her crystal. Repeat this until she runs away.
In your final encounter with Shriek, she temporarily takes away your Black suit, and figures from your imagination attack you (your loved ones). You can kill them with one hit, but it is pointless. Wait until the Black suit recharges, then switch over, revealing your true enemies. Attack Shriek until she changes you back to the old Spider-Man. Repeat the previous steps and she will collapse.
Defeating the technology person
Dodge him and wait until he shoots missiles at you. Press Attack to send them back. This will cause him to land, allowing you to hit him. Keep doing this until he dies.
Defy gravity
While web swinging with Spider-Man, press Z for the boost and hold it. When you reach the end of your swing, press C and rotate the Nunchuck to the Left or Right, while still holding Z + C. Spider-Man will start to look like he is having a spasm and will remain at the end of his swing, defying the laws of gravity. Play around with the Z + C combination to do different things, such as moving like a ceiling fan while under the monorail.
Easy gang eradication
Immediately after you defeat The Sandman for the first time in the "Mary Jane's Favorite Band" mission and before you "Meet Mary Jane At The Restaurant", you cannot take off the Black suit. During this time period, which does not end until you start the next mission, you can wear the Black suit without any damage being done to you. Use this time to clear the city of all gang activity. This may take awhile, but it is easier with the Black suit.
Easy Hero Points
Play through Story mode and take every boss' picture and any gang members desired, but make sure to leave at least one. After completing Story mode, take any remaining pictures you have not taken to get around 15 Hero Points. Then, save the game and reset your Wii. Load your saved game file and you should hear and see the Villain Photos complete and get another 15 Hero Points. Spend them, save, and repeat the process as many times as desired.
Easy kills
To easily defeat enemies jump then keep tapping both Attack buttons.
Fight against Michael
When you are trying to open the boarded up windows, if you are far away from him he will do a long jump towards you. Then it takes him a few seconds to recover to attack. Before he jumps, do not stand in the yellow circles. Instead, stand next to the wall opposite the windows. He will now jump to there, recover, etc. While he is recovering, pull down the boards. When he jumps into the light, attack him. Keep doing this until his and his wife's life runs out to complete the level.
Fight against Sandman
In your first encounter with Sandman, do not try to attack him, just stay close to him. Counter-attack him several times on different levels to finally battle him. Unfortunately, you must use the Black suit to damage him. Just hit him around until you are prompted to give him a bath. Keep doing this cycle until you defeat him.
Fight against Venom
Before this battle, go to the upgrade menu and make sure you have the melee attack volley. Then, fight. Depending on your health level, you may or may not want to use the power up. At the moment, you can easily jump over Venom, confuse him, and chip away at his health. Keep doing this until his black suit begins to "glow". Now when you jump over him he will run away. This is a good opportunity to use your new attack and chip at him, occasionally giving some hits. Keep hitting him until his "glow" gets bigger and eventually Harry will tell you to knock Venom into the air. He'll fall back to the ground same as before, easily confused. Repeat this cycle until his health is really low and you can finish him off.
Finding Metorite Pieces
While playing as Black suit Spider-Man, you can find the Metorite Pieces (small rock-like objects surrounded by a purple/pink glow) by listening for a pulsating sound. The louder it gets, the closer you are.
Play as Venom
Collect all 100 metorite pieces.
Random gang
If you go to a crime area that is already been taken over by the police, you may still answer, but it will be challenges with a random gang. Note that nothing will happen to the area once you complete the mission.
Rival gang reward
Choose any of the gang patrol missions (Apocalypse, Dragon Tail, H-Bombers, Waste Tribe), and defeat all of their marked territories that match their logos to earn 3 experience points.
Token collection
While swinging through the city you might hear a chime. This indicates that you are close to a token.
Unlock black suit spider-man after you destroy the suit
Collect all 50 spider emblems.
Unlock Symbiote Spider-Man's story mode
Successfully complete the game as Spider-Man to unlock Symbiote Spider-Man's story mode.
Web swinging upgrades
You can earn upgrades for this ability by using it a lot.