Undead Rayne
In any level where Rayne can jump onto an object that is slanted enough so that she cannot stand on it and against a wall, have her jump onto it and land between it and the wall. She will continue to slowly flail her arms as if she were falling, and eventually she will just fall to the side dead saying "Rayne needs to feed!". Then the "Game Over" menu will appear. The best place to try this is The Meatpacking District: Alleys and Rooftops, where there are several white poles sticking against walls.