If you want to activate a cheat, you do not have to worry about your progress. You can still complete all missions in full. However, you can no longer pass the Slayer gates and thus deny yourself the opportunity to get hold of all the sky keys.

Effect	Code
A single projectile hit, explosions, the flame spout or dash immediately make demons tumble. Has no effect on unique bosses.	Immediate drowsiness
All Praetor Suit Perks are unlocked.	Fully Upgraded Suit
All Runes unlocked.	All Runes
All weapons are unlocked and mastered, and all equipment is unlocked.	IDKFA
An invisible audience cheers based on how you play.	QuakeCon Mode
Demons burst into confetti on full body gib, lower body gib, upper body gib, limb loss, and fatal headshots.	Party Mode
Demons do not drop health or armour on death.	Famine Mode
Infinite Berserk powerup on map start. Only works on Hell on Earth, Exultia, Super Gore Nest, ARC Complex, and Mars Core.	Powerup Mode: Berserk
Infinite Onslaught powerup is active for the whole mission.	Powerup Mode: Onslaught
Infinite Overdrive powerup is active for the whole mission.	Powerup Mode: Overdrive
One hit from projectiles, explosions, Flame Belch, or dashing instantly staggers demons. It has no effect on unique bosses.	Instant Stagger Mode
Player has infinite Extra Lives.	Infinite Extra Lives
Sentinel Armour is active for the whole mission.	IDDQD
Staggered demons die from a single hit from projectiles, explosions, Flame Belch, or dashing.	Silver Bullet Mode
Toggles all of the unlocked cheat codes.	Activate All Cheats