Getting the Rose's Syringer unique weapon
The Rose's Syringer unique weapon can be obtained at the "Top Of The World" resort, which is located in the center of the map in the Savage Divide region. The quest for the special syringer is given by a Raider Robot named "Rose" on the top floor of the resort. Talk to Rose, and she will send you on three Raider faction quests: "Signal Strength", "Flavors Of Mayhem", and "Keys To The Past". Complete all her quests to get Rose's Syringer. Most syringers are not too useful, but this syringer turns any enemy shot with it extremely powerful for 60 seconds, and then extremely weak for 60 seconds. As long as you can survive the first 60 seconds, even high-level enemies can then easily be killed. This allows Level 10-20 players to kill Level 40-50 enemies. Note: While at the "Top Of The World" resort, you can also find a Vault-Tec Bobblehead on the Mezzanine Level, on a speaker near the elevator exit.
Strategy Tips
Tip 1: Collect as Many Materials as Possible: Materials are extremely valuable in Fallout 76. You will encounter vendors, but everything you really need is carried by enemies or found as loot. To earn XP, kill enemies and explore areas. It is recommended to stay in the opening area for as long as possible. Unlock, hack, loot, and kill everything in the area for easier levels. Looting is not too useful on its own. There are vendors, but selling stuff is not always useful. Instead, get a crafting bench and scrap useless items. Base materials are used for crafting, and they are far lighter than standard items like weapons or armor. You can carry lots of base materials, which is very helpful early in the game.
Tip 2: Create Bulk Bundles: You can use a Tinkerer Workbench for more than just scraping items. You can also transform base materials into a "bulk" bundle. Use the "bulk" function to place a lot of base materials into a single bundle with just 1 weight. This allows you to carry multiple bundles of bulk materials with almost no weight. You can also store the bulk bundles in your stash for later.
Tip 3: Upgrade Skills Wisely: Place your skill points into Perception and Intelligence first to unlock Hacking and Lockpicking (two very important skills). If you want to loot everything and explore all areas, lockpicking and hacking are mandatory. Unlock perks related to those activities first, then upgrade your Strength. Strength not only allows you to kill enemies more easily so you can save ammo, but it also unlocks the Rat Pack perk at Level 8. This perk increases your carrying capacity, which is very helpful when you have to often carry most of your stuff around.
Tip 4: Move Your Camp to Quicksave: Your camp can be used like an item, and dropped down at a new location as you explore. This allows you a safe place to sleep and save your game, allowing you to respawn at the campsite most recently used. Use your portable camp regularly as you explore, or before getting into a dangerous fight, so you can save and do not have to start too far away or lose a lot of progress if you die.
Tip 5: Get a Gun at the Start: After leaving Vault 76, there is a corpse with a gun to your right. It only has approximately eight bullets, but if you miss this weapon, you will have to fight enemies with your fists at the start.
Tip 6: Get Power Armor Early: You can get some Power Armor shortly after leaving Vault 76. Go to the Morgantown Trainyard, which is straight east of Vault 76. There is a partial Power Armor suit inside the train car with "USA" labeled on the side. It contains a frame, helmet, and few random armor pieces.
Tip 7: Get a Hazmat Suit: The Hazmat Suit completely protects against the negative effects of radiation. It can be found in the Poseidon Energy Plant WV-06. You do not actually have to go inside to get the suit. Simply travel to the plant (it is the huge nuclear power plant on the west side of the map, just off the river). After entering the plant grounds, stay to the left side to find an exterior catwalk. Follow it up and around to the first roof landing to find a small exterior trailer-like office. There is a Hazmat Suit sitting on some boxes inside.
Tip 8: Get a Mini-Gun: While you are in the Poseidon Energy Plant, there is a common Mini-Gun that spawns in this area. From the rooftop while wearing the Hazmat Suit, go up the catwalks to find a balcony with a burnt corpse standing on the edge. A Mini-Gun will sometime spawn on the wooden crates in this area. If it does not appear, it can spawn in a different nearby location. Proceed up to the second rooftop, then go to the catwalks above the interior office door. A Mini-Gun will sometimes spawn on the landing with the sitting corpse. There is one other area the Mini-Gun regularly spawns. Go up the catwalks until you reach one that spirals around a tower. At the top is a dead end with a few crates. The Mini-Gun at this location spawns very often.
Tip 9: Get Free Materials from Responder Bots: This is only useful early in the game, but sometimes you will encounter Responder Bots that try to help you. These bots are useful if you are struggling, and will sometimes even give you free items. Talk with Responder Bots before killing them to sometimes get materials, which you cannot loot off their bodies after killing them.
Tip 10: Get a Bobblehead: Bobbleheads spawn in semi-random locations in Fallout 76, but there is a bobblehead that spawns in a common location at the County Fair (large Ferris Wheel on the map). The Bobblehead can be found on the table covered with old Halloween decorations inside the shed/metal building on the edge of the fairground.
Getting the Laser Minigun...