Alternate endings
Deplete Lucas' sanity bar in the restaurant when the game starts. He will then be committed into an insane asylum.
In the "Lost Love" level, keep drinking the alcohol under the counter in the kitchen, without taking the medication. After the meter is depleted, Lucas will commit suicide by jumping off the balcony.
In the "Confession" level, get your meter as low as possible. While talking with Marcus, select the "Sick" and "Break Off" options and Lucas will turn himself in to the police.
Deplete Carla's sanity meter and she will resign from the NYPD.
Deplete Tyler's sanity meter. Tyler and Sam leave New York and go to Florida.
Omikron The Nomad Soul reference
Early in the game when you wake up as Tyler, there is a desk in the bedroom with an action figure. Examine it, and he will say "This is a figurine of Sox, a character from my favorite videogame." Sox is a robot from another game by Quantic Dream, Omikron The Nomad Soul.
Tarot cards
Look at the following locations to find the corresponding tarot card. The number indicates its value.
Lucas' apartment in the kitchen cupboard (5)
Lucas' apartment on the balcony (10)
Central Park in the alley on the right (20)
Naser and Jones at a stall in the open space (5)
Naser and Jones in a toilets box (10)
Cemetery near Markus (5)
Agatha's House in the kitchen (5)
Agatha's House in the bathroom (20)
Naser and Jones in Lucas' desk (10)
Agatha's House in Agatha's bedroom (10)
Tiffany's apartment in the street (20)
The museum in the room (5)
The Fun Fair near a fence (20)
The Subway on the rails (20)
Police Station in the hall (10)
Police Station desk drawer (5)
Gymnasium behind the ring (10)
The Archives in the boxes near the locked door 10)
Carla's Apartment in the bathroom (10)
Police Station in the open space (20)
The Lavomatic in the cart (10)
Bellevue Asylum in the corridor (10)
Tyler's apartment in the bathroom (10)
Police Station desk drawer (5)
Takeo's Shop on the first floor (20)
Takeo's Shop near the stairs (20)
Police Station in the open space (5)