Unless your scenario terrain won't permit it, always start up a transportation network with trains rather than trucks. They're faster and carry more.

Place your factories with long-range considerations in mind, straddling several metropolitan areas.

Placing a store right next to an identical one owned by the competition can mean you share up to 90 percent of their
customers.

Use the info icon regularly to view your opponents' product pricing. You can undercut them; they can also deliberately
set out to undercut you.

Tunnels and bridges will reduce travel costs and delivery lag.

Upgrade your transportation network whenever airports and docks become available.