| Achievement | How to unlock
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| - Destroy 10 environment pieces.
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- Dead Prince of San Hermanos
| - Kill the prince and complete the game.
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| - Destroy 50 environment pieces.
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| - Destroy 100 environment pieces.
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| - Complete the first mission.
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| - Complete all side missions.
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| - Complete the Spice questline.
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| - Heal 100 mercenaries in doctor mode.
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| - Heal 50 mercenaries in doctor mode.
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| - Heal 5 mercenaries in doctor mode.
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