| Achievement | How to unlock
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- Bam, bam, bam, bam and... bam!
| - Be awarded with an extra chain reaction
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| - Reach the last wave difficulty in the 5 challenges
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| - Earn all diamond medals for the DNA chain defense
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| - Earn all chain reaction diamond medals in story mode
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| - Earn all chain reaction gold medals in story mode
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| - Destroy one virus pathogen in sample 11, 12 or 13
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| - Earn all diamond medals in story mode
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| - Earn all time diamond medals in story mode
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| - Earn all time gold medals in story mode
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| - Complete sample 12 without touching a single sticky web
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| - Reach a gold rating in the 5 challenges
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| - Earn all gold medals in story mode
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| - Complete sample 21 without colliding with a single flagellate pathogen
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| - Buy at least one point in every skill
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| - Earn all life gold medals in story mode
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| - Complete sample 14 without slowing the chain
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| - Reach the maximum levels for all skills
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| - Be awarded with 20 macroshots in a single level
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| - Complete sample 17 without being poisoned once by toxins
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| - Complete sample 8 without destroying a single bloated cell
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| - Earn all life diamond medals in story mode
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| - Destroy 6 critical cubes in any sample of the story mode
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| - Complete the game in hard shooter difficulty
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| - Complete the game in hard puzzle difficulty
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| - Complete sample 25 without using the EMP
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| - Complete the game with no shield size reduction
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| - Complete the game with no upgrade for cube speed
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| - Reach a diamond rating in the 5 challenges
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| - Complete the game with both difficulties set to hard
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- Who needs life upgrades ?
| - Complete the game with no life upgrade
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