Parano is a very difficult Boss. Her weakness is Red or Fire. First, kill the four robots when you go in the room, then worry about Parano. You can only use Red to attack her. She gets mad after you hit her; get you shield ready. You need a lot of Recovery Pills if you are not very experienced. Keep attacking her with Red, then when she is hurt a lot she will start to spin and fly at you. Use your shield to block her. If you block her the first time, she will fly in circles around you. Start to charge your Red when she is doing this. As soon as she lands, you will be able to hit her if you are mentally locked on.