To completely defeat Mysterio, first you will go to an autotorium. Press triangle + circle to grab reporters. Once you've freed them all, destroy the robots. (every time you punch you will stay in mid-air so it makes it easy to destroy them). Once you've beaten him, you will go to lady liberty. swing from the robots in the air by using all of your different kinds of web swings. From there, destroy more in-the-air robots. Then jump in the middle of lady Liberty's head and dodge the sweeper to atack the brain. Then you will go to his apartment and destroy the clowns, mirrors, and axes. For a while, you won't see Mysterio, but all of a sudden he will rob a store and all you have to do is give him a charge kick and he will be destroyed for good!