Tip 1
Attempt to unlock all characters. Triumphing with Isaac is definitely possible, however you might choose other characters.

Tip 2
Beating Mother for the very first time is just the start. The game does not even consider it a "Mother Kill." You need to now beat Mama's Heart in subsequent playthroughs. The more times you beat Mama's Heart, the more you unlock.

Tip 3
Azazel, a new character to Rebirth, is outstanding during that he can fly over any challenge to obtain at items you may otherwise need to pass on.

Tip 4
When you're in a room with mobile enemies, move around a lot. Standing still is ensured to obtain you eliminated. Feel free to avoid tablets if you feel like you're having a truly great run. Occasionally they have unfavorable results and can destroy your playthrough.

Tip 5
Keep and take notes track of all the tarot cards. Some are excellent, some are bad, and some are GREAT.

Tip 6
You might have some difficulty with Rebirth in that case if you're not a visual student ... well. However just with a name and photo when you use an item it's included to the item list. Do your finest to keep in mind exactly what each item does, and jot down descriptions if that assists.

Tip 7
Explode blue flames for a possibility at soul hearts.

Tip 8
Blow up the middle of walls in an effort to discover secret spaces if you have an abundance of bombs.

Tip 9
Handle the devil are the utmost risk/reward. You lose a heart, however the items provided during that room are commonly great.