If your chosen character class is a Monk, use the following skill setup to become very effective against almost all enemies. To start with, set the Primary Attack to Way of the Hundred Fists and attach the Rune Hands of Lightning. For the Secondary Attack, choose Wave of Light with the Explosive Light rune attached to it. For Skill Button 1, choose Blinding Flash with Blinding Echo as the attached rune. For Skill Button 2, choose Exploding Palm with Strong Spirit as the attached rune. There are various options for Skill Button 3. If facing a Boss, choose Mystic Ally with your choice of rune. In normal game play, choose Seven Sided Strike with the Several Sided Strike rune attached to it. For Skill Button 4, choose Mantra of Retribution with the Retaliation rune attached to it. For Passive Skills, choose Transcendence, Seize the Initiative, and Pacifism. This setup will allow you to handle any situation that is thrown at you. Note: If surrounded, use the secondary attack. It will clear the area and heal you at the same time. Blinding Flash is also very useful.