Leech Hunter Mode...
	Rebecca's Team Wesker Costume...
	Rocket Launcher...
	Submachine Gun...
	Various Trophies...
	Wesker mode...
	Zombie gets stuck in corner...

Beat the game on any difficulty to unlock leech hunter mode. Load the Clear game save file then select Extra Mode to start the leech hunter mode.

Beat Wesker mode.

Beat the game in 3:30 hours or less on Normal or Hard difficulty to unlock the Rocket Launcher. When you load the Clear game save file and select Once Again to start a new game, you will find the Rocket Launcher in Rebecca's inventory.

Beat the game in 5 hours or less on Normal or Hard difficulty to unlock the Submachine Gun. When you load the Clear game save file and select Once Again to start a new game, you will find the Submachine Gun in Billy's inventory.

Complete the following tasks to unlock PlayStation 4 trophy rewards.

Trophy	How to unlock
Allergic to First Aid Spray (Silver)	Finish the game without using a First-Aid Spray.
Apprentice of Unlocking (Bronze)	Obtain all keys and use them all.
Burned Alive (Bronze)	Defeat an enemy by burning them.
Dead, Dead, Deadski (Bronze)	Defeat a zombie by stomping on them.
Fashion Plate (Bronze)	Change into a costume.
Fileophile (Bronze)	Read all files.
Find Time to Combine (Bronze)	Combine every type of herb with each other.
From Zero to Hero (Silver)	Finish the game on Hard difficulty.
Guns are Too Quick (Bronze)	Defeat an enemy with a knife.
Here I Come to Save the Day (Bronze)	Attack an enemy to save your partner who is grappling with that enemy.
I Could Shoot, You Know (Silver)	Obtain all weapons.
I'm a Medic, Not a Bodybuilder (Bronze)	Try to push something heavy with Rebecca.
Misdirected Hostility (Bronze)	Destroy a zombie's legs.
S is for S.T.A.R.S. (Silver)	Finish the game with rank S.
Save Your Prayers (Gold)	Finish the game without saving.
This is How You Recycle (Bronze)	Create a Molotov Cocktail.
This is Serious Business (Silver)	Finish the game without using a recovery item (including Green Chemicals).
Wanna Go for a Ride? (Platinum)	Earn all trophies.
Who's Got the Herb? (Silver)	Finish the game without combining herbs.
Zero In (Bronze)	Defeat an enemy with a critical-hit headshot.

Beat the game on any difficulty to unlock Wesker mode.

In the water treatment plant, right after Rebecca takes the lift downstairs, when she changes the camera angle, she can lure the zombies back to the area near the lift. However, the zombies will not be able to enter the camera frame close to the lift. She can stand at that position and continue to knife the two zombies without getting injured or hit even once. Similarly, in the steam room in the water treatment plant with the lift, position Billy or Rebecca near the lift facing toward the screen. Have your character stand next to the dangling florescent tube and lure the zombies to come from the door. The zombies will get stuck at the corner of the railing and can be stabbed until they are all dead. This helps to conserve ammo.