Display the Seed entry prompt at the "Character Select" menu. Then, enter one of the following seed codes to activate the corresponding cheat function. Note: Some codes may delete your saved game file.

Effect	Code
30 minute limit	30M1 N1TS
All enemies have permanently feared	FEAR M1NT
All floors have the basement room tile set	BASE MENT
All items except troll bombs mimic Issac's movement	KEEP AWAY
Asocial enemies	CLST RPH0
Axis aligned controls	AX1S ALGN
Big head mode	T0PH EAVY
Black body	PTCH BLCK
Bravery	BRAVERY
CRT display	B00B T00B
Camouflage EVERYTHING!	WH0A WHAT
Camouflage enemies	CAM0 F0ES
Camouflage player	CAM0 K1DD
Camouflage stuff	CAM0 DR0P
Can destroy rocks	NFB8 3WSG
Cathode rays!	B00B T00B
Champion enemies	CHAM P10N
Character and tears turn black	PTCH BLCK
Character leaves fecal trail	BRWN SNKE
Character only visible as brown shadow	CAM0 K1DD
Character takes double damage	HARD HARD
Charmed enemies	C0CK FGHT
Christmas	CHRS TMAS
Concussive enemies that move randomly	C0NF ETT1
Confused enemies	C0NF ETT1
Cowardice	C0WR D1CE
Damage on a timer	THEG H0ST
Dog Mode	ALM1 GHTY
Don't stop moving	D0NT ST0P
Doors open immediately, tears are harmless; Boss's health act as timers	PAC1 F1SM or PAC1 F1ST
Downtempo--	LARG HET0
Downtempo	ANDA NTE
Dyslexia	DYSL EX1A
Easier game	1337 HAXR
Eligible enemies become champions	CHAM P10N
Enemies become feared randomly	FRAI DN0T
Enemies fight each other	C0CK FGHT orCLST RPH0
Enemies only visible as brown shadows	CAM0 F0ES
Enemies respawn when character leaves room; new items do not drop	C0ME BACK
Enemies respawn	C0ME BACK
Escape the Labyrinth	THRE AD
Extra Gore	BL00 00DY
F2P version	FREE 2PAY
Farty sounds	FART SNDS
Forever Unknown	VNKN 0WN
Full heart damage	HARD HARD
Glowing tears	TEAR GL0W
Grayscale	KAPP A
Grey character	KAPP A
Heal the Blind	BRA1 LLE
Health tempo	HART BEAT
Hopelessly Lost	L0ST
Horrible Curse	CVRS ED
I once was Lost	F0VN D
Ice Physics	1CES KATE
Illuminate Darkness	N1TE L1TE
Incurable Blindness	BL1ND
Inescapable Labyrinth	LABY RNTH
Infinite Basements	BASE MENT
Invisible character except for surrounding light effect	1MN0 B0DY
Invisible enemies	BL1N DEYE
Invisible enemies	BL1N DEYE
Invisible player	1MN0 B0DY
Jumbled in-game text	DYSL EX1C
Kids' co-op mode	K1DS M0DE
Know the Unknown	N0W1 KN0W
Large pools of blood when enemies die	BL00 00DY
Load screen always displays "Are You Sure You Want Me To Die?"	1TEN DSHE or SUPA SWAG
Movement tempo	SL0W 4ME2
Mystery cards	FACE D0WN
Mystery pills	MED1 C1NE
No HUD	KEEP TRAK
Pacifism	PAC1 F1SM
Permanent Darkness	DARK NESS
Pickups time out	G0NE S00N
Pill names and descriptions appear as ???	MED1 C1NE
Point of no return	N0RE TVRN
Poopy Trail	BRWN SNKE
Reversed controls	DRAW KCAB
Reversed controls	DRAW KCAB
Scaredy enemies	FEAR M1NT
Skittish enemies	FRA1 DN0T
Slow motion while character is idle; music speed altered with movement speed	SL0W 4ME2
Sound effects replaced with farts	FART SNDS
Start with 69 coins and have to purchase all items and pickups	FREE 2PAY or PAY2 PLAY
Stay out of the Maze	PATH F1ND
Take damage when idle	D0NT ST0P
Tarot cards are face down when collected	FACE D0WN
The Blank	THEB LANK
The lower your health, the slower the music	HART BEAT
Ticking starts every 45 seconds, after 5 seconds character takes half heart of damage	THEG H0ST
Tiny head mode	T1NY D0ME
Total curse Immunity	BLCK CNDL
Tricky pickups	KEEP AWAY
Twelve heart damage	BRTL B0NS
Unending Maze	MAZE
Uptempo++	PRES T0
Uptempo	ALLE GR0