Each time a run is started you are given a choice of boosts that can be purchased. The auto shield can be useful, as well as a restart.
Costumes
Costumes award you with a permanent score multiplier. Obtain them as soon as possible to increase the number of points you earn per game. You can then get power-ups that will increase the duration of the power-ups that are collected.
Goo
If you get stuck in pink goo, swipe to increase Sackboy's speed to avoid getting eaten. Take care because pink goo is usually followed by spikes and obstacles, often making it necessary to jump as soon as you escape.
Jumping
A longer tap will result in a higher jump than a short tap. However a long tap followed by a swipe is even more useful when the gaps between platforms get larger. Higher platforms usually contain more bubbles, bonuses, and enemies than the lower ones. Use jumping points or ramps to get as high as possible.
Shield
Your shield is charged by collecting coins. When full, activate it as needed. The shield meter will not begin filling again unless it has been depleted.
Traps
"No Sackboys" signs will indicate the presence of traps that will immediately end your run. To survive, make sure your shield is activated. Those areas usually contain better rewards.
Upgrades
Start by upgrading the magnet because it is power-up that is found most often.
Various Trophies
Complete the following tasks to unlock Vita trophy rewards.
Trophy
How to unlock
60 Minute Mile (Bronze)
Play Run Sackboy! Run! for an hour.
All mine! (Silver)
Collect 50,000 bubbles in total.
Bubble hoarder (Bronze)
Collect 10,000 bubbles in total.
Employee of the month (Bronze)
Reach level 20.
Escape artist (Bronze)
Near miss the Negativitron 25 times.
Extra life (Bronze)
Use 10 Save-Me Hearts.
L Plates gone (Bronze)
Reach level 2.
Maximum power! (Silver)
Fully upgrade one power-up.
Run Sackboy! Run! (Silver)
Run a total of 100,000 metres
Sackboy the Destoryer (Bronze)
Destroy 1000 enemies.
Shields up! (Bronze)
Deflect a missile with a shield.
Stickers mean prizes! (Bronze)
Collect the reward for completing a sticker theme.
Boosts...