Easy Win
After completing the game you will be prompted to select a cheat. Choose teleportation. You will have to press your special and R to use it. If you are playing two player or exhibition mode, set the match to one round. Hit your opponent a few times then keep teleporting for the rest of the round and you will win.
When creating a boxer, give him a the Body Blaster as his special move. During the match, throw a few jabs and back away. Wait for your opponent to move in and hit him with the Body Blaster. It should stun him. Hit him with it again. Continue to do this and you will knock him out in no time. This can be done in all three weight divisions and works almost all of the time. Also, if you find yourself in trouble, try the Backhand (elbow) followed by the Body Blaster. It either takes off a good amount of energy or stuns them, leaving them open for the Body Blaster.
When creating a new boxer, select the Cake Mixer as his special hit combo. When your opponent is about to get knocked down, hit him with the Cake Mixer. About 90% of the time, he will do a spin in the air and fall to the mat.
When creating a new boxer, select Macho as his special hit combo and set your speed and power stats up. Throughout the fight, keep using the special. The combo is so quick your opponent cannot react to it, giving your an easy win.