Complete the game on "Fugitive" difficulty to unlock the "Dead On Arrival" and the "New York Minute" settings.
Bonus Bullet Time Level
Complete the game on "New York Minute" difficulty to unlock a bonus level where you have to kill a lot of enemies, all in bullet time.
Cheat Mode
Start a game. Press Back during the game to display the main menu. Then, hold L and R, click Left Analog-stick and click Right Analog-stick, then quickly press White, Black, Black, White, White, and Black at the main menu. The cheat menu will appear, which contains "All Weapons" and "Refill" options. To access these cheats, press Back during gameplay and select the options you want at the cheat menu. Then, press Back to resume playing. Other cheat menu options must be unlocked during gameplay.
Fight the Rats
In Part 1 Chapter 2, at the very beginning, throw a grenade (you must use the "All Weapons" cheat to have one) in the hole in the brick wall in front of you. Select Show Objectives, and a new objective will appear: a war against rats. Continue the level and pass the sewer, then go up the stairs. There you will find armed rats to battle.
Infinite painkillers
To get infinite painkillers you have to press start during a game then press white, white, black, A, B, X, Y, Y ,Y, R, and then right by your health bar it will say 100+.
Level Skip
During gameplay, press Start. Then hold L and press Black four times, X six times, Y three times and then Back. When you're at the Main Menu, go back and a sound will confirm that you've completed the current chapter.
Secret Ending
Complete the game on "Dead on Arrival" difficulty, using no codes, and you will be transfered to the "Final Battle." There you must fight several enemies in permanent bullet time. If you can defeat them, a door will open, revealing a secret finale.
The Devil Level
If your stuck on the first or second level were you have to walk on the lines of blood here is how you beat it, if you are on the first level of the blood lines then if you look to your left at just the right angle you can see another door, walk acroos to that side to get tto that door and then the rest is just the halls. If your on the second blood line level the time slows alot mor annd you have to keep jumping till your at the bottom level of blood lines. Walk the opposite direction of the door you walked into the bllood line area in and you should find a big circle of candles. Just jump onto the crib on press "a". Then your at the next part and out of the blood line level.
Weapon and Refill Codes
At the main menu screen (the screen where you can select new game, resume game, ect.) hold down both of the thumbsticks and both triggers (L & R) at the same time. Then, while holding the thumbsticks down and holding both triggers down press White, Black, Black, White, White, Black. This code will work if you do it right.
This will open an additional menu at the bottom of the screen. Once you get into the cheat code screen, you can select two things; all weapons and refills. An explanation for each is described in the game when you highlight it in the menu.
In order to use the cheats, you must first start a game. Then, once your new game has started press the back button on the controller to access the main menu. Then go into the cheat menu and activate the codes by pressing the A button on the cheat you wish to activate.
Additional Difficulty Settings...