Get a special and do one (but not the 619). Get your opponent on the ropes and do the 619. When your opponent is done rolling, quickly go to the other side and jump out onto the apron (like a tag partner). Make sure you have the move where
he pulls back on the ropes, jumps, and does a leg drop. Get about in between him (stomach but slightly higher) and do the leg drop move. You should hit him on the head (as seen on SmackDown The Dime Drop). Quickly pin him and you should
win.

The following are good moves to give Rey Mysterio:

Corner
Grappling 1: West Coast Pop
Grappling 2: Rico Moonsault
Standing
Grappling 1: Tiger Bomb or Tiger Driver
Grappling 2: Kidman Face Crusher
Ropes/Apron
619