Effect: Enemies do saving throws

Where to find: Tsavo Highway

On Tsavo Highway, about halfway through the mission (right after you are forced to walk through a large blue barrier), you will come out of a tunnel on the highway, and see a large pipeline on your left. Drop down in between the two, and run to the wall in front of you. Follow the wall all the way to where it connects with the cliff on your right, and turn to the left. There should be a few ledges--simply crouch jump from ledge to ledge, and the last one should have the "Tough Luck" skull on it.