To skip the first Jean Grey fight Murder World (Act 2 Part 1) before you enter "Dooms Castle" you MUST have one or more characters that can teleport (Night Crawler, Deadpool, or Dr. Strange) also they must be alive when you reach the first Jean Grey encounter. After thats done when you start the encounter have your hero that can teleport run to the door on the opposite side of the room and teleport past it (for Night Crawler and Deadpool press the "Y" button twice and if its Dr. Strange and he has the Teleportation ability hold "right trigger" and press "X" with the teleportation ability selected, if it isn't hold "right trigger" and press "left" or if you don't know your directions its "<--" on the D pad). Once you are behind the door press "X" and your free to continue but you don't get loot from Jean.