During the game you can find eighty emblems which are hidden in the four campaigns (Chris, Leon, Ada and Jake) For every chapter in that campaign you are able to collect four Serpent Emblems. If you find one then you have to shoot it with one of your weapons. The total of collected Serpent Emblems can be found at your "Extra Conent" / "Records" menu.
Alternate ending
Complete Ada Wong's campaign to view a video after the credits.
Alternate sniper rifles uses
The sniper rifle is useful for inflicting damage on distant enemies, but incorporating the quick-shot action will double its use as a close-quarter weapon. This will substitute any shotgun, the Desert Eagle, and the Elephant Killer when ammo is scarce for them. Piers' anti-material rifle is a one hit-kill on most enemies near or far.
Curious Fan title
To unlock Curious Fan title you have to beat Resident Evil 5 Campaign.
Defeating Gassers
Aim for a Gasser's head and keep shooting until it kneels. Shoot again to finish it off. Kill them quickly because they can turn humans into zombies.
Dodge All Enemy Attacks
During a fight/battle, press the View Button to access your phone. Once pressed, all nearby enemies will no longer attack you and shift their focus onto your partner. This can be done at any time.
Dog tag titles
Complete the indicated task to unlock the corresponding title on your dog tag.
Title
How to unlock
Action Junkie
Complete 200 campaign chapters.
Amateur
Complete all 20 campaign chapters on Amateur.
Amazon
Complete 15 campaign chapters with female characters.
Any Port in a Storm
Use chrysalids for cover for 20 minutes.
Badass
Attack 100 times with zero stamina.
Big Baby
Crawl for 300 meters.
Bone Breaker
Kill 100 enemies while sliding.
By Any Means
Use an enemy's weapon 100 times.
Chuter Shooter
Kill 100 parachuting enemies.
Combat Master
Perform a unique physical attack 300 times.
Counter Attacker
Perform 300 counterattacks.
Curious Fan
Finished playing Resident Evil 5 campaign.
Dead Ringer
Be killed 200 times.
Death Wish
Require saving 100 times.
Decorated Agent
Earn all 175 different medals in the campaign.
Earning Them Medals
Earn 2,000 medals.
Easy Target
Require help 300 times.
Enemy Expert
Get 300 kills.
Enjoying the Scenery
Walk 5,000 meters.
Executioner
Perform 300 coups de grâce.
Face Smasher
Destroy 1,000 J'avo masks.
Figure Collector
Collect all 78 figures.
File Collector
Read all 80 files.
Fire Hazard
Set 1,000 zombies on fire.
Getting Good Grades
Complete all 20 chapters in the campaign with an S rank.
Global Player
Play with 300 other players online.
Going Out in Style
Be killed awesomely 50 times.
Got Some Experience
Complete all 20 campaign chapters on Normal.
Gunslinger
Hit enemies with a quick shot 1,000 times.
Hardcore Player
Play Resident Evil 6 for 100 hours.
Headshot Master
Make a headshot 1,000 times.
Herb Sharer
Feed your partner 200 health tablets during the campaign.
Hero
Rescue another player 300 times.
I Got Hand
Kill 100 enemies with Piers' mutated arm.
I Know What I'm Doing
Complete all 20 campaign chapters on Veteran.
J'avo Juice
Play as a J'avo 300 times.
Joyrider
Travel 500 kilometers with a vehicle.
Kickin' Ass & Takin' Names
Defeat 10,000 enemies.
Last Hurrah
Defeat 100 enemies while dying.
Left My Mark
Tag 300 enemies with a marker.
Lifesaver
Save other players from dying 100 times.
Like a Duck to Water
Swim 1,000 meters.
Lone Wolf
Complete all 20 campaign chapters by yourself.
Mad Dasher
Dash for 5,000 meters.
Manipulator
Use an enemy's attack to kill 300 other enemies.
Medal Agent
Earn 1,500 medals in the campaign.
Metal Muncher
Destroy 300 helicopters or tanks.
My Skills
Earn a total of 200,000 skill points.
Need a Pick-Me-Up
Consume 2,000 health tablets.
Need My Meds
Use the first aid spray 100 times.
Not an Acrobat
Use the zip-line 300 times.
Open Season
Kill 300 animals.
Party Time!
Play with 3 other players X times during a story intersection.
People Eater
Play as a zombie 300 times.
Phoenix
Recover on your own from dying 100 times.
Potent Pugilist
Land a physical attack 1,000 times.
Professional
Complete all 20 campaign chapters on Professional.
Props to You
Praise your partner 100 times during the campaign.
Relentless Attacker
Perform 300 successful follow-up attacks.
Reloader
Reload 5,000 times.
Rescue Me
Receive help 300 times.
Resident Evil
Default title.
Respect the Skills
Complete all 20 campaign chapters without seeing the game over screen.
Resuscitated Agent
Saved from dying 100 times.
Rock-Hard Buns
Traverse 500 meters on your backside.
Rollin' with the Homies
Play online with a friend X times.
Running My Shoes Off
Run 100,000 meters.
Skill Collector
Purchase 80 skills.
Slide 'n' Smash
Destroy 300 objects while sliding.
Slip Slider
Slide 500 times.
Stealth Killer
Perform 300 stealth kills.
Tag Master
300 enemies you tagged are killed by other players.
The Chemist
Combine herbs 1,000 times.
Title Collector
Earn 200 titles.
Undercover
Use cover for a total of 100 minutes.
Weapon Expert
Get 1,000 kills.
Easy "B.O.W.s Are Ugly" achievement
Play the final chapter of Chris' storyline and progress to checkpoint 5-1. Continue until you enter a circular room surrounded by levers. You will be ambushed, and each lever will spawn two Chrysalid B.O.W.s. You can pull the levers yourself. After killing all ten of them reload from the last checkpoint and repeat the process. Do not enter the next area or you will get a new checkpoint and have to repeat the entire first section of the level. Your kill progress will be saved even if you do not reach a new checkpoint.
Easy "Hard Choice" achievement
In Jake's campaign, when fighting the helicopter in Chapter 4 at the part where you see Chris, get on the top of the roof. You will find some ladders and boxes to destroy. The helicopter will sometimes drop enemies on ropes. Get near one of those ropes and press [Action]. Then, climb up and shoot the pilot.
Easy "I Prefer Them Alive" achievement
In Chapter 2 of Leon's campaign, after entering the cathedral, you must solve some puzzles to open the main chamber door in the center of the altar. Afterwards, you will encounter the Lepotitsa. It infects many humans in a short time by releasing C-Virus gas. You must save at least two females in the cathedral. To do this,, shoot at it as fast as possible while remaining at a safe distance. However, do not position yourself too far away or you will lose sight of it and it will infect too many people. If you do enough damage, it will expose its weak areas and get on its knees. When this happens, get close and perform a melee attack for increased damage. Note: This will require a large amount of ammunition under the higher difficulty settings. Consider doing this after completing the campaign, in order to have better weapons and perhaps unlimited ammunition.
EX - 2 outfits for all characters
Play with a friend or play with strangers but one thing is for sure, you have to win.
Outfit
How to unlock
Ada EX 2
Survivors: Win 5x.
Chris EX 2
Survivors: Win 10x.
Helena EX 2
Survivors: Win 10x.
Jake EX 2
Team Survivors: Win 5x.
Leon EX 2
Survivors: Win 5x.
Sherry EX 2
Team Survivors: Win 10x.
Extra Content stages
Complete the indicated task to unlock the corresponding stage. Note: Levels must be unlocked separately for each Extra Content type (Mercenaries, Siege, Predator)
Stage
How to unlock
Stage 4: Rail Yard
Complete Mining the Depths with a "B" rank.
Stage 5: High Seas Fortress
Complete Rail Yard with a "B" rank.
Stage 6: Catacombs
Complete High Seas Fortress with a "B" rank.
Stage 7: Requiem for War
Complete Catacombs with a "B" rank.
Stage 8: Liquid Fire
Complete Requiem for War with a "B" rank.
Stage 9: Rooftop Mission
Complete Liquid Fire with a "B" rank.
Stage 10: Creature Workshop
Complete Rooftop Mission with a "B" rank.
Faster reload animation
You can prematurely "cut" a reloading animation by quickly selecting a grenade type item (grenade, remote mine, first aid spray) and then switching back to your firearm. As an alternative, you may also attempt to press [Fire] without aiming to perform a gun-butt with the weapon, which also "completes" the magazine reload, but places your character in the gun-butt animation. This, and other actions (taking cover, diving, etc.), may be faster or slower than weapon switching, but will depend on the situation you are in. This is especially useful in the very fluid situations in Mercenaries mode. This animation exploit allows you to cut down the animation cool-down periods for certain weapons (notably the grenade launcher), allowing you to fire the weapon a few moments earlier. This exploit does not apply to weapons with manually worked actions, such as the six-shot "sniper rifle", the regular shotgun, Piers' Anti-Material Rifle, etc.
Hidden Video
After you have defeated every Four campaigns a video clip will become unlocked which will start right after every credit video from any of the campaigns.
Infinite Ammo
Once you completed all the four Tale modes you will enable the options unlimited ammo at your "Skill Settings".
Infinite Ammo skill
Complete all four campaigns to unlock the Infinite Ammo skill for each weapon.
Megaman series reference
As you enter the "Special Features" menu, then enter the "Collections" menu, you will be taken to a canteen named "Xover". Capcom is planning on titling the next Megaman game for the Apple iPad and iPhone Megaman Xover.
Mercenaries Mode Bosses
When you complete the following task in the indicated level you will unlock the corresponding hidden Boss.
Napad (Urban Chaos)
Get 15 Counter Kills before 80 kills.
Strelat (Catacombs)
Get 20 Quick Shot Kills.
Ubistvo (Rail Yard)
Get 25 Quick shot kills before 80 kills.
Gnezdo (Steel Beast)
Get 25 Coup de grace attacks before 80 kills.
Gnezdo (High Sea Fortress)
Get 40 melee kills before 80 kills.
Strelat (Mining the Depths)
Kill 70 enemies before 600 seconds.
Mining the Depths Map
To unlock Mining the Depths Map you have to beat Jake's Campaign on any difficulty.
Various Achievements
Complete the following achievements to unlock Microsoft Gamerscore points.
Achievement
How to unlock
A Revolting Development (15 points)
Complete Chapter 2 in Jake's campaign.
Ada's Demise (15 points)
Complete Chapter 4 in Ada's campaign.
After Her! (15 points)
Complete Chapter 3 in Chris' campaign.
B.O.W.s Are Ugly (30 points)
Defeat 100 enemies that have come out of a chrysalid.
Back in My Day (30 points)
Complete the entire game on Veteran.
Big Trouble in China (15 points)
Complete Chapter 4 in Leon's campaign.
Bob and Weave (15 points)
Counter an enemy's attack three times in row.
Bring the Heat (15 points)
Take down an enemy from 50 meters away with a headshot using the thermal scope.
Buried Secrets (15 points)
Complete Chapter 2 in Leon's campaign.
Check Out My Dogs (15 points)
Customize your dog tags.
Civilian Casualties (30 points)
Defeat the BSAA 100 times.
Counterintelligence (15 points)
Complete Chapter 2 in Ada's campaign.
Covered in Brass (30 points)
Earn 150 different medals.
Down, Not Out (15 points)
Defeat an enemy while dying, then recover without any help.
Duty Calls (15 points)
Complete Chapter 5 in Chris' campaign.
Easy Pickings (30 points)
Eliminate all players as Ustanak in less than a minute.
Everybody Dies (45 points)
Defeat 100 player-controlled agents and 100 player-controlled creatures.
Finish What You Start (15 points)
Perform a coup de grâce on ten enemies.
Flying Ace (15 points)
Pilot the VTOL without getting a scratch on it.
Get on the Plane (15 points)
Complete Chapter 3 in Leon's campaign.
Give a Little Push (15 points)
Knock ten enemies off a high place.
Gone to Hell (15 points)
Complete Chapter 1 in Leon's campaign.
Green around the Ears (15 points)
Complete the entire game on Amateur.
Hard Choice (15 points)
Shoot the helicopter pilot with a Magnum at point-blank range.
Heirlooms (30 points)
Collect all the serpent emblems.
Held Captive (10 points)
Defeat Ustanak with only one Agent remaining.
High Voltage (15 points)
Defeat ten enemies with a stun rod charge attack.
I Prefer Them Alive (15 points)
Rescue two female survivors at the cathedral.
I Spy (15 points)
Complete Chapter 1 in Ada's campaign.
Invincible (30 points)
Defeat Ustanak without anyone on your team being captured.
J'avo Genocide (15 points)
Defeat 500 J'avo.
Kill or Be Killed (10 points)
Win while in the dying state.
Killer Combo (30 points)
Achieve a 30-combo chain.
Kung Fu Fighting (30 points)
Survive to the end only using physical attacks.
Last Man Standing--Again (45 points)
Win five times in a row.
Leave It to the Pro (90 points)
Complete the entire game on Professional.
Let's Blow This Joint (15 points)
Complete Chapter 3 in Jake's campaign.
Lifesaver (15 points)
Help or rescue your partner ten times.
Mad Skillz (90 points)
Max out all the skills that allow you to level up.
Money Talks (15 points)
Complete Chapter 1 in Jake's campaign.
Murder Spree (30 points)
Defeat the BSAA as a creature without dying once.
Normal Is Good (30 points)
Complete the entire game on Normal.
Not without a Fight (45 points)
Defeat Ustanak 20 times.
One Is Better Than None (15 points)
Purchase one skill.
One Is Never Enough (10 points)
As Ustanak, capture a total of 50 humans.
Protect and Serve (10 points)
Protect the BSAA without any of them getting hurt.
Rescue the Hostages (15 points)
Complete Chapter 1 in Chris' campaign.
Rising Up (30 points)
Earn a level-four title.
See You Around (15 points)
Complete Chapter 5 in Jake's campaign.
Silent Killer (15 points)
Use a stealth attack to take down five enemies.
Sneaking Around (15 points)
Get through the aircraft carrier's bridge area without being noticed.
Staying Alive (10 points)
Return to the game as a human character.
Still on the Run (15 points)
Complete Chapter 4 in Jake's campaign.
Stuntman (15 points)
Defeat 20 enemies with the Hydra using a quick shot.
Surrounded on All Sides (45 points)
Send 2,000 enemies to your opponent's map.
Take 'Em All Down (30 points)
Defeat 100 agents.
Take the Stage (30 points)
Defeat your opponent and achieve victory in 3 stages.
Team Effort (10 points)
Win without any members of your team being killed.
The Longest Night (10 points)
Complete the tutorial.
The Trouble with Women (15 points)
Complete Chapter 5 in Leon's campaign.
There's Always Hope (15 points)
Complete Chapter 4 in Chris' campaign.
They're ACTION Figures! (15 points)
Collect 3 figures.
This Takes Me Back (15 points)
Complete Chapter 3 in Ada's campaign.
Titular Achievement (15 points)
Earn 10 different titles.
Tragedy in Europe (15 points)
Complete Chapter 2 in Chris' campaign.
Two Sides of the Same Coin (10 points)
Win 10 times.
Weapons Master (30 points)
Use all the weapons in the game and kill ten enemies with each of them.
What's Next? (15 points)
Complete Chapter 5 in Ada's campaign.
You Are S.O.L. (10 points)
Defeat your opponent 10 times with enemies you sent.
