The solution for the animal puzzle is Deer, Wolf, Horse, Lion, Snake, Eagle.
Avoid Leech Zombie explosion
When you fight the Leech Zombie, its legs will swell up at the end and explode, hurting and often killing you or your partner. There are three ways to avoid this. First, just leave as his legs are swelling but before he explodes. The second is to use a Molotov cocktail on him, which will light him on fire and melt into a puddle of slime and leeches. The third way is to kill him while he is still in "human" form, which is best done with the magnum and has the end effect as the Molotov cocktail. Run through a door when it is swelling. Make sure that nothing is attacking you or your partner when doing this, Return to the room and there will be no extra leeches will no one hurt.
Better hunting gun use
If you have the hunting gun with unlimited ammunition from the Leech Hunter mini-game, equip Rebecca with it. She shoots faster than Billy. Billy shoots once per second, while Rebecca can shoot about two or three times per second.
Better shotgun use
Once you get the shotgun, do not use it. Instead, leave it in the room with the scale you put the two figures on. Find, but do not pick up, lots of shotgun ammunition. After you save her from the pit, give all the hand gun ammunition to Billy and collect the shotgun ammunition. If you get it all, she will have about 60 rounds, which is much better than using two hand guns.
Custom handgun
When you are in the draining room in the facility basement, you will find the Duralumin case. You have to enter a code, which is 385. The case will open and you will find handgun parts. Combine these with Billy's handgun for a more efficient handgun.
Easy Leech Zombies kills in hard mode
From the beginning of the game onward, you will find a lot of empty bottles. Do not ignore them. Pick them up and combine them with the gas can for the Molotov cocktails. Two of these will take out a Leech Zombie. Also, it will not explode as usual; you no longer need to run away. It will also kill a zombie with one hit or two zombies at once if you hit directly between both of them. Note: This weapon can harm you or your partner if thrown too closely.
Fountain circle puzzle
When you get to the fountain circle with the six animal statues on Disc 1, use Billy to light the statues in the following order: Deer, Wolf, Horse, Lion, Snake, Eagle.
Items
In the train there are items. If you do not need them, select them but do not take them. When the train crashes, items will be scattered around the wreck. Those are the items that you selected. The items not selected will disappear. This is very important if playing under the hard difficulty setting.
Longer life
When you start the game as Rebecca, get to the point where you meet Billy. He will say that they need to cooperate. When Billy joins you on your mission, it is best if you have him in control at all times. Because he has stronger defense and will not get damaged as fast as Rebecca. Note: This works in all modes.
Pause timed puzzles
Try to change to your partner during a timed puzzle. Remain idle at the error message to give yourself more time to study the puzzle.
Piano room
When you get to the piano room, make sure you have both characters with you. Have Billy play piano. A door will open by the bar. Have Rebecca go in and take the battery. The door will close. Have Billy play piano again and the door will open.
Resident Evil 2 areas
When you eventually get onto the moving cable car, after Billy is taken over the railing by an ape, go across the ravine and head up the pair of steps. You will enter a big room with a metal floor. This is the same area in Resident Evil 2, where you call up the platform train to head down into the main factory (and where you fight a stronger version of the William Birkin mutations). If you go towards the bottom of the screen and go down the lift and into the back room, you will find a television screen with a picture of a Tyrant. This is the same room where you see Mr. X walking towards the camera before smashing it. If you call up the platform and take it down, you will enter the factory sub-levels and walk into the room where Leon/Claire had to carry Ada/Sherry to the security room.
Safer and faster shotgun reload
To reload the shot gun faster, press Y to go to the item screen. Combine the shotgun ammunition with the shotgun. You will be able to attack again without having Billy or Rebecca reload and waste precious time.
Save ammunition on first Leech zombie on the train
After the sequence with the first Leech zombie, just go back downstairs and the intermission sequence will take place again.
Saving ammunition
Equip the handguns to both Rebecca and Billy. Control Billy. When you see a zombie, shoot him until he falls, but do not kill him. Then, equip the pocket knife and kill the zombie with it. This will save about two to five bullets each time. There are two knife tactics you can use to safe ammunition for the Bosses. The first tactic is used fighting solo without the help of Billy or Rebecca; depending on whom you use. Make sure you keep about two steps away from the zombie and aim downward with your knife. Slice him once then he will make a failed attempt to lunge at you. Then, slice his feet again and he will fall down. Once down, do not knife him any more. Instead take about a step backward and wait for him to get up and repeat this process again. This tactic works if there are multiple zombies. Alternately, if there is only one zombie you move to behind the zombie's head when he is laying down. Then, knife his head and keep knifing him as he gets up. When done properly you will knife his feet twice and he will fall down again. This will allow a few extra shots in as you knife his head while he gets up. The second knife tactic is used fighting with a team. The person you control should be using a knife, and either Billy or Rebecca should be using a gun (and set on attack mode). Get in front of the one with the gun and knife the zombie's feet. As you knife the feet, your partner will shoot the head and the zombie will fall down. Then, go over and knife the zombie while he is on the ground. As he gets up keep knifing him and your partner's help will assist you in finishing him off properly.
Various Trophies
Complete the following tasks to unlock PlayStation 3 trophy rewards.
Trophy
How to unlock
Allergic to First Aid Spray (Silver)
Finish the game without using a First-Aid Spray.
Apprentice of Unlocking (Bronze)
Obtain all keys and use them all.
Burned Alive (Bronze)
Defeat an enemy by burning them.
Dead, Dead, Deadski (Bronze)
Defeat a zombie by stomping on them.
Fashion Plate (Bronze)
Change into a costume.
Fileophile (Bronze)
Read all files.
Find Time to Combine (Bronze)
Combine every type of herb with each other.
From Zero to Hero (Silver)
Finish the game on Hard difficulty.
Guns are Too Quick (Bronze)
Defeat an enemy with a knife.
Here I Come to Save the Day (Bronze)
Attack an enemy to save your partner who is grappling with that enemy.
I Could Shoot, You Know (Silver)
Obtain all weapons.
I'm a Medic, Not a Bodybuilder (Bronze)
Try to push something heavy with Rebecca.
Misdirected Hostility (Bronze)
Destroy a zombie's legs.
S is for S.T.A.R.S. (Silver)
Finish the game with rank S.
Save Your Prayers (Gold)
Finish the game without saving.
This is How You Recycle (Bronze)
Create a Molotov Cocktail.
This is Serious Business (Silver)
Finish the game without using a recovery item (including Green Chemicals).
